Ecological studies of the naturally occurring radionuclides, 137Cs and heavy metals in soil,plants and milk in surrounding of Kragujevac city,Serbia

Journal of Radioanalytical and Nuclear Chemistry - Vertical distribution of natural radionuclides, 137Cs and heavy metals were measured in soil and plants collected from Kragujevac surroundings....     

Glass transition kinetics and fragility index of chalcogenides from Ag–As–S–Se system

Journal of Thermal Analysis and Calorimetry - The glass transition temperature dependence on a heating rate was investigated by differential scanning calorimetry for chalcogenide glasses from the...     

A preliminary survey of natural radionuclides in soil and indoor radon in the town of Niš, Serbia

Journal of Radioanalytical and Nuclear Chemistry - The activity concentration of natural radionuclides in the samples of soil from the town of Ni? were measured using the gamma spectroscopy...     

Half-sandwich ruthenium(II)-arene complexes: synthesis,spectroscopic studies,biological properties,and molecular modeling

In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes are gaining increasing recent interest. In this work, we report on the synthesis, characterization (¹H- and ¹³C-NMR, FT-IR), and cytotoxicity studies of two new half-sandwich organometallic Ru(II) complexes of the general formula [Ru(η⁶-arene)(XY)Cl](PF₆) where arene?=?benzene or toluene and XY?=?bidentates: dipyrido[3,2-a:2′,3′-c]phenazine (dppz) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool” configuration of Ru(II)-arene complexes—as confirmed by vibrational and NMR spectra. In addition, cytotoxic studies were performed for similar half-sandwich organometallic [Ru(η⁶-p-cymene)(Me₂dppz)Cl]PF₆ complex (Me₂dppz = 11,12-dimethyl-dipyrido[3,2-a:2′,3′-c]phenazine). This study is complemented with elaborate modeling with density functional theory (DFT) calculations, which provided insight into reactive sites of Ru(II) structures, further detailed by molecular docking on the B-DNA dodecamer, which identified binding sites and affinities: most pronounced for the [Ru(η⁶-benzene)(aip)Cl](PF₆) in both A-T and G-C regions of the DNA minor groove. Cytotoxic activity was probed versus tumor cell lines B16, C6, and U251 (B16 mouse melanoma, C6 rat glioma, U251 human glioblastoma) and non-tumor cell line HACAT (HACAT normal human keratinocytes).     

A note on hybridization process applied on transformed double step size model

Numerical Algorithms - We introduce a hybrid gradient model for solving unconstrained optimization problems based on one specific accelerated gradient iteration. Having applied a three term...